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Its oral bioavailability is only 25 to 35% with marked interindividual differences.
This is similar to the rate for normal mucosa obtained here, but with more interindividual variation.
Wide ranges in interindividual responses to the various opioids have been noted.
Already, Zilles has discovered that there is much more interindividual variation in human brain organisation than anyone suspected.
Wide interindividual variability in response to both the analgesic and adverse effects of opioids is recognized.
These strains have provided homogenous experimental groups, with interindividual variability reduced to environmental (and stochastic) factors.
A single oral dose of thioguanine has incomplete metabolism, absorption and high interindividual variability.
An alternative rationale suggested for the use of esomeprazole was the reduction in interindividual variability in efficacy.
There is a wide interindividual variation, however, in breath H 2 excretion, when given a constant dose of lactulose repeatedly.
A large intra- and interindividual variation is found, as reported in all previous pharmacokinetic studies of the different 5-ASA formulations.
The other 85 percent will then split half and half (42.5 percent) between the intra- and interindividual within-population comparisons.
Intraindividual and interindividual analyses of positive and negative affect: Their relation to health complaints, perceived stress and daily activities.
Kegan presents a sequence of six evolutionary balances: incorporative, impulsive, imperial, interpersonal, institutional, and interindividual.
Their subject-specific PBPK explained 91% of the observed data variability and found interindividual toxicokinetic differences.
Neither interspecific differences nor interindividual differences in LPS responses have, until recently, been accessible to systematic genetic analysis.
Until more is learned about the pathophysiology of SMNs and the interindividual variation in susceptibility, targeted preventive strategies are limited.
It has been shown in rodents that the size of the mossy fiber projections can show large interindividual variations, which are to a large part heritable.
Latent Growth Curve Methodology can be used to investigate systematic change, or growth, and interindividual variability in this change.
The lack of correlation between turnover of enzyme pools and secretion is perhaps due to interindividual variation in enzyme pool sizes.
Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed.
He reflected that the progressive extension of the field of individual development and experience was regressively accompanied by a restriction of the converse domain of interindividual relations.
An autosomal study in 2011 found an average Northwest African influence of about 17% in Canary Islanders with a wide interindividual variation ranging from 0% to 96%.
Genetic studies, including the investigation of polymorphisms in genes encoding for xenobiotic metabolizing and DNA-repair enzymes, may provide valuable information on genotype-environment interactions and interindividual susceptibility.
Although there is much interindividual variability, it is generally true that α-spectrin mutations result in an inability of α-spectrin to interact properly with β-spectrin to form a heterodimer.
There is not yet any real understanding of how brain patterns change over time in an individual, or how interindividual differences should be interpreted in relation to the conclusions that are valid for groups.