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Therapy with interferon-alpha is another treatment option, especially for patients with intercurrent infection.
This is particularly associated with the child's age and the presence or absence of intercurrent infection, which is often seasonally related.
Insulin-resistant diabetes developed, and the patients died during childhood of ketoacidosis and intercurrent infections.
Manifesting as a sudden fall in the haemoglobin value with no compensatory reticulocytosis, these are usually secondary to intercurrent infection, most commonly with parvo virus.
Subsequent events tended to recur at the time of intercurrent infections, at which time the flow rate of oxygen was increased; none subsequently required cardiopulmonary resuscitation.
As with many non-sexually transmitted opportunistic infections, intercurrent infections with sexually transmitted pathogens (especially pathogens that cause genital ulcers such as herpes simplex, syphilis, and chancroid) can stimulate increases in HIV viral load and consequent declines in CD4+ count.