inositol trisphosphate

(1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals.

Coupling of the receptors to this protein mediates inositol trisphosphate signalling.

(1984) Inositol trisphosphate and diacylglycerol as second messengers.

Although inositol trisphosphate diffuses into the cytosol, diacylglycerol remains within the plasma membrane, due to its hydrophobic properties.

Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell.

(1983) Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.

Upon activation of phospholipase C by various cell surface receptors, inositol trisphosphate is formed that releases calcium from the endoplasmic reticulum.

The enzyme phospholipase C produces diacylglycerol and inositol trisphosphate, which increases calcium ion permeability into the membrane.

The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP) and extracellular lipophilic hormones like steroid hormones.

The docking of IP to its receptor, which is called the inositol trisphosphate receptor (InsP3R), was first studied using deletion mutagenesis in the early 1990s.

The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol trisphosphate.

Recent studies have shown that the spine apparatus is also able to release Ca through inositol trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs).

THE ryanodine receptor (RYR) is almost twice as large as the inositol trisphosphate receptor (IP 3 R).

A decrease in cNMPs is triggered by α-gustducin and a rise in IP(Inositol trisphosphate)/DAG results from βγ-gustducin.

Melatonin can activate phospholipase C which acts to generate inositol trisphosphate (IP3) which opens IP3 sensitive calcium channels in the endoplasmic reticulum.

FIG. 1 Summary of the two major receptor-mediated pathways for stimulating the formation of inositol trisphosphate (InsP 3 ) and diacylglycerol (DAG).

It is predominantly found bound to G proteins of class G, which use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway.

Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca channel activated by inositol trisphosphate (InsP3).

And one can show that it has a discrete inhibitor specificity compared with the inositol trisphosphate gated calcium channel in that this one is specifically inhibited by a plant alkaloid known as rhinadin.

It comprises G coupling, phospholipase C activation, intracellular calcium release from inositol trisphosphate receptor-sensitive stores, CaMKII activation and BDNF production.

He is best known for his work on cellular transmembrane signalling, in particular the discovery that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane with the release of Ca within the cell.

Like the M muscarinic receptor, M receptors are G proteins of class G that upregulate phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway.

PLC is a critical signaling enzyme that hydrolyzes membrane phospholipids to generate inositol trisphosphate (IP 3 ), which binds to IP 3 receptors and increases intracellular Ca 2+ [ 24 ] .

Previously, we showed that RSG3 was expressed endogenously in rat pituitary cells and, when experimentally co-expressed together with GnRH receptors in a heterologous cell line (COS1), it suppressed GnRH-stimulated inositol trisphosphate production [ 9 ] .