immunosenescence

Less efficient immune function (Immunosenescence) is a mark of old age.

A decline in the human immune system that occurs with aging is known as immunosenescence.

Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement.

Immunosenescence is a multifactorial condition leading to many pathologically significant health problems in the aged population.

Consistent reports of the positive relationship between regular physical activity and immunosenescence have generated much excitement in the field of exercise immunology.

( See also Immunosenescence )

Some of the age-dependent biological changes that contribute to the onset of immunosenescence are listed below:

T-cell components associated with immunosenescence include:

Among various phenomena, he identified signal transduction pathways inside T-lymphocytes that determine cell proliferation, programmed cell death, or immunosenescence.

In fact, age-related alterations are evident in all stages of T-cell development, making them a significant factor in the development of immunosenescence.

This phenomenon called immunosenescence is largely due to a decline of T cell function, including the capacity for T cells to properly support germinal center responses.

Some of the association between aging and cancer is attributed to immunosenescence, errors accumulated in DNA over a lifetime, and age-related changes in the endocrine system.

For example, defects in T cell proliferative capacity/responsiveness, cytokine production and receptor expression, signal transduction and cytotoxicity are frequently cited associations with immunosenescence.

Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria.

Everolimus was used in a recent clinical trial by Novartis, and short-term treatment was shown to enhance the response to the influenza vaccine in the elderly, possible by reversing immunosenescence.

The ability of the immune system to respond to pathogens is diminished in both the young and the elderly, with immune responses beginning to decline at around 50 years of age due to immunosenescence.

Older people tend to become less responsive to vaccination, a phenomenon known as immunosenescence, and are expected to benefit particularly from a vaccine that provides direct access to the immune system through the dermal skin layer.

Immunosenescence is not a random deteriorative phenomenon, rather it appears to inversely repeat an evolutionary pattern and most of the parameters affected by immunosenescence appear to be under genetic control.

The Immunology of Aging Updated March 1999 1997 Review Articles Immunosenescence Immunology Today [IMMUNOL.

This brief review explores the interactions between cortisol and DHEA and their effects on immune function in aging, as well as potential methods to combat the endocrine-related contribution to immunosenescence, including DHEA supplementation and exercise.