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Ichthyosis acquisita (or "acquired ichthyosis") is a disorder clinically and histologically similar to ichthyosis vulgaris.
In some cases, paraneoplastic acanthosis nigricans (35% of patients), Florid cutaneous papillomatosis, Ichthyosis acquisita (Acquired hypertrichosis lanuginosa), Cowden syndrome, Tylosis, Acrokeratosis paraneoplastica of Bazex and Tripe palms accompanies the sign of Leser-Trélat.