hypotrophy

The progressive symmetrical distal muscular weakness and, ultimately, proximal muscle weakenss, can appear as muscle hypotonia and hypotrophy.

Adipocyte hypotrophy was attributed primarily to reduced triacylglyceride content in WAT from lipolysis, while adipocyte differentiation did not play a role in reduced adipose tissue despite the effects of prostaglandins on adipogenesis.

ADF in rats "prolongs life span and promotes numerous health benefits in rodents, including tissue protection from ischemic damage" but also has negative effects including causing "myocardial hypotrophy, cardiac fibrosis, diastolic dysfunction, and a reduction of cardiac reserve."