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To read more about this topic, see: allergy and hyposensitization.
Desensitization or hyposensitization is a treatment in which the person is gradually vaccinated with progressively larger doses of the allergen in question.
Comparison of EPD with conventional escalating-dose immunotherapy (hyposensitization)
In 1918, Dr. Cooke suggested a mechanism of action for allergen injections as a "desensitization or hyposensitization," analogous to tolerance achieved in experimental anaphylaxis induced in animals.
By contrast uncontrolled use of conventional (escalating dose) immunotherapy (hyposensitization not EPD) for general allergic conditions was believed to be responsible for at least 29 deaths in the UK, and is now banned in the United Kingdom except in hospital under close observation.