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Tbx20 knockout mouse embryos die at around or before E10.5 with hypoplastic hearts.
If part of the endocardial tube gets pinched shut in a region that becomes the future ventricle, hypoplastic heart syndrome will occur.
Loma Linda University Medical Center made international news on October 26, 1984, when Dr. Leonard L Bailey transplanted a baboon heart into Baby Fae, an infant born with a severe heart defect known as left hypoplastic heart.