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By 1960, despite additional treatments, the patient had worsened and thus became a candidate for a hypophysectomy.
"I believe she stands a very real chance of another remission by hypophysectomy," wrote one of his colleagues.
"The disabilities caused by hypophysectomy and their repair"
Furthermore, obesity in rats was significantly reduced by adrenalectomy or hypophysectomy.
Hypophysectomy is the surgical removal of the hypophysis (pituitary gland).
Was the hypophysectomy worthwhile?
Hypophysectomy is the destruction of the pituitary gland, and has been used successfully on metastatic breast and prostate cancer pain.
Hardy J: Transsphenoidal hypophysectomy.
Medications that are given as hormone replacement therapy following a complete hypophysectomy (removal of the pituitary gland) are often glucocorticoids.
Houssay demonstrated in the 1930s the diabetogenic effect anterior hypophysis extracts and the decrease in diabetes severity with anterior hypophysectomy.
The fourth case of visual changes on orbit was significant for a past history of transsphenoidal hypophysectomy for macroadenoma where postoperative imaging showed no residual or recurrent disease.
"I wonder if patient could tolerate such a procedure emotionally," wrote a doctor about Mrs. E., a 44-year-old breast cancer patient being considered for a last-ditch brain operation called a hypophysectomy.
Rats lacking adequate vasopressin, either due to genetic defect or hypophysectomy (surgical removal of the pituitary gland), exhibited significant improvements in memory and learning functions when exogenous vasopressin was administered.
He worked on developing hypophysectomy with Harvey Cushing, and they and Samuel James Crowe published the first evidence of the link between the pituitary gland and the reproductive system in 1910.
Jarrahy R, Suh R, Berci G, Shahinian HK: Endoscopic pituitary surgery: An in vivo model for transnasal transsphenoidal hypophysectomy.