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According to her death certificate, Jane died of hyperpituitarism and gigantism.
Hyperpituitarism evidently ran in the Pyne family.
Hyperpituitarism is the primary hypersecretion of pituitary hormones.
Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism.
When there is an enlargement of the pituitary tissue, hyperpituitarism is often associated with:
Most notably, extreme height may be pathological, such as gigantism resulting from childhood hyperpituitarism, and dwarfism which has various causes.
Suffering from hyperpituitarism, Payne works at S.T.A.R. Labs searching for a cure.
Alternatively, excessive growth can have several causes, most commonly resulting in hyperpituitarism (overactivity of the pituitary gland controlling hormone production) with excess secretion of hGH.
In children with hyperpituitarism, disruption of growth regulation and/or sexual maturation is common, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
A scientist suffering from hyperpituitarism, Preston Payne used the second Clayface's blood to create a cure but became a claylike creature that needed to pass his condition onto others to survive instead.
Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary.
It was not until 1915, nine years after her accident that scientists definitely determined that the pituitary gland is responsible for producing growth hormones in humans, and though the problem was identified, no treatment was available for hyperpituitarism during Jane's lifetime.