hyperoxaluria

Primary hyperoxaluria: effect of treatment with vitamin B6 and shock waves.

There are three main types of primary hyperoxaluria, each associated with specific metabolic defects.

Type II hyperoxaluria is caused by mutations in this gene.

A child with primary hyperoxaluria was treated with a liver and kidney transplant.

Renal transplant is more effective and this is the primary treatment of severe hyperoxaluria.

Individuals with hyperoxaluria often have calcium oxalate kidney stones.

Primary hyperoxaluria is a rare autosomal recessive condition which usually presents in childhood.

Mild metabolic hyperoxaluria and its response to pyridoxine.

Defects can be associated with primary hyperoxaluria type III.

Control of hyperoxaluria with large doses of pyridoxine in patients with kidney stones.

Primary hyperoxaluria results in increased excretion of oxalate, with oxalate stones being common.

Young roots of Rubus idaeus prevented kidney stone formation in a mouse model of hyperoxaluria.

These include tumor lysis syndrome, acute phosphate nephropathy, and occasional cases of enteric hyperoxaluria.

It has also been used to treat certain hereditary disorders (such as xanthurenic aciduria, cystathioninuria, hyperoxaluria, homocystinuria).

Hyperoxaluria that can potentially lead to oxalate nephropathy and irreversible renal failure is the most significant abnormality seen on urine chemistry studies.

This excess glyoxylate is then oxidized by lactate dehydrogenase to produce the oxalate that is characteristic of hyperoxaluria.

Because oxalic acid is produced in the metabolism of vitamin C, hyperoxaluria can be caused by intravenous administration of ascorbic acid.

Primary hyperoxaluria (A service of the U.S. National Library of Medicine)

The main therapeutic approach to primary hyperoxaluria is still restricted to symptomatic treatment, i.e. kidney transplantation once the disease has already reached mature or terminal stages.

Factors that promote the precipitation of oxalate crystals in the urine, such as primary hyperoxaluria, are associated with the development of calcium oxalate stones.

The reduced enzyme function can be caused by a rare inherited autosomal recessive disorder known as primary hyperoxaluria type II (PH2).

(National Urea Cycle Disorders Foundation) What Is Hyperoxaluria and Oxalosis?

Yendt ER, Cohanim M. Response to physiologic dose of pyridoxine in type I primary hyperoxaluria.

They can result from an underlying metabolic condition, such as distal renal tubular acidosis, Dent's disease, hyperparathyroidism, primary hyperoxaluria or medullary sponge kidney.

There is some evidence that taking pyridoxine alone or combined with magnesium can decrease the risk of kidney stones in people with type I primary hyperoxaluria, a hereditary disorder.