hypermutability

This somatic hypermutability can thereby lead to an increased risk of cancer at an early age in virtually every organ, including the skin.

Overexpression of PMS2 results in hypermutability and DNA damage tolerance.

Microsatellite instability is the condition of genetic hypermutability that results from impaired DNA Mismatch Repair (MMR).

The directed mutagenesis hypothesis was challenged in 2002, when John Roth and colleagues showed that the phenomenon was due to general hypermutability due to selected gene amplification, and was thus a standard Darwinian process.