hydroxylation

Hydroxylation also has a great effect on the biological activity of the gibberellin.

It is still studied largely because of its interesting hydroxylation polymorphism.

The "alternative" pathway begins with the hydroxylation of the cholesterol side chain.

Two mechanisms have been proposed as the primary pathway of hydroxylation in P450 enzymes.

The first four seem to be involved in the hydroxylation of toluene to benzyl alcohol.

A minor pathway that occurs is the hydroxylation of the N-methyl.

In fact, hydroxylation is sometimes followed by dehydrogenation, leading to more complex metabolites.

One example is the hydroxylation of benzene by Fenton's reagent.

Phytoceramide is produced in yeast by hydroxylation of dihydroceramide at C-4.

This compound has also been prepared in acceptable yield via oxidative hydroxylation of the 2-acetylbutyrolactone.

A hypothetical hydroxylation is shown in this illustration.

These hydroxylation reactions are catalyzed by two different enzymes: prolyl-4-hydroxylase and lysyl-hydroxylase.

The CLK-1 enzyme is responsible for the hydroxylation of 5-demethoxyubiquinone to 5-hydroxyubiquinone.

Hydroxylation of biphenyl oxide has been studied in C. echinulata.

Based on the observations of what happens when there's no substrate, or oxygen, the following steps seem to constitute the hydroxylation reaction.

To avoid additional chiral center a hydroxylation at the adamantyl ring was carried out (Figure 5).

The rate limiting step in catecholamine biosynthesis is hydroxylation of tyrosine.

Erythromycin 12 hydroxylase is responsible for the C-12 hydroxylation of the macrolactone ring.

In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases.

Hydroxylation is the first step in the oxidative degradation of organic compounds in air.

Some drugs (e.g. steroids) are activated or deactivated by hydroxylation.

The principal hydroxylation agent in nature is cytochrome P-450, hundreds of variations of which are known.

The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation.

Amination and hydroxylation has been observed for substituted pyrimidines.

A recent hydroxylation example involves the oxidation of barbituric acid to alloxane.