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He also demonstrated that human hookworm infection is contracted through the skin of the feet.
Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm.
The life cycle is similar to that of the human hookworms, Necator americanus and Ancylostoma duodenale.
Ancylostoma duodenale and Necator americanus are the two human hookworms that are normally discussed together as the cause of hookworm infection.
Worldwide, N. americanus is the predominant etiology of human hookworm infection, whereas A. duodenale occurs in more scattered focal environments [3].
The nematode parasites Necator americanus and Ancylostoma duodenale cause human hookworm infection which leads to anaemia and protein malnutrition.
Etiology and Global Distribution Human hookworm infection is caused by blood-feeding nematode parasites of the genus Ancylostoma and the species Necator americanus .
Together with Philip K. Russell, Hotez founded the Human Hookworm Vaccine Initiative (HHVI) in 1999, the first initiative of the Sabin Vaccine Institute PDP.
Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A. New technologies for the control of human hookworm infection.
As a complementary strategy, the Human Hookworm Vaccine Initiative (HHVI) is developing a safe, efficacious, and cost-effective vaccine, the Na -ASP-2 Hookworm Vaccine, that would provide an additional tool for the control of hookworm [29,30].
Peter Hotez (Distinguished Research Professor and Professor of Microbiology, Immunology, and Tropical Medicine at The George Washington University School of Medicine, and Principal Scientist and Founding Director of the Human Hookworm Vaccine Initiative)
Sabin advocates for the control of vaccine-preventable diseases such as HPV, pneumococcal disease, pertussis, rotavirus, rubella and typhoid and neglected tropical diseases (NTDs) including human hookworm infection, ascariasis, trichuriasis, schistosomiasis, onchocerciasis, lymphatic filariasis (elephantiasis) and trachoma.