human TSH

Recombinant human TSH, commercial name Thyrogen, is produced in cell culture from genetically engineered hamster cells.

The 1999 release of recombinant human TSH, Thyrogen, in the USA, can boost the uptake to 50-60% allowing the therapy with Iodine 131.

An ultramicro RIA for human TSH was published in BBRC (1975) by Drs. Acebedo, Hayek et al.

A synthetic drug called recombinant human TSH alpha (rhTSHα or simply rhTSH, (trade name Thyrogen), is manufactured by Genzyme Corp.

Since Graves' disease is an autoimmune disease which appears suddenly, often quite late in life, it is thought that a viral or bacterial infection may trigger antibodies which cross-react with the human TSH receptor (a phenomenon known as antigenic mimicry, also seen in some cases of type I diabetes)