histaminergic

Histaminergic cells can be recorded firing just before an animal shows signs of waking.

Histaminergic action is known to modulate sleep.

It has been shown that histaminergic cells have the most wakefulness-related firing pattern of any neuronal type thus far recorded.

It has been reported that histaminergic neurons have the most wake-selective firing pattern of all known neuronal types.

The increased amounts of histamine released from histaminergic nerve endings can stimulate receptors.

From here, these histaminergic neurons project throughout the brain, to the brain through the medial forebrain bundle.

Nortriptyline may also have a sleep-improving effect due to its affinity for 5HT and histaminergic receptors.

Finally, during REM sleep, histaminergic neurons stop firing altogether.

Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.

Eugeroics appear to function primarily by increasing catecholaminergic (adrenergic, dopaminergic) and histaminergic activity in the brain.

It also has high affinity for H histaminergic receptors equal to that at 5-HT receptors.

Duloxetine is superior to many other medications for the treatment of fibromyalgia due to its freedom from muscarinic, histaminergic and adrenergic adverse reactions.

Clozapine also is a strong antagonist at different subtypes of adrenergic, cholinergic and histaminergic receptors, the last two being predominantly responsible for its side effect profile.

Thioperamide enhances the activity of histaminergic neurons by blocking autoreceptors, thus preventing the detection of histamine by neurons.

It consists of, largely, histaminergic neurons (i.e., neurones releasing histamine) and is involved with the control of arousal, sleep and circadian rhythm.

Activation of these neurons increases dopamine and norepinephrine in these areas, and excites histaminergic tuberomammillary neurons increasing histamine levels there.

Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.

Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects.

The histamine H receptor is an inhibitory autoreceptor located on histaminergic nerve terminals, and is believed to be involved in modulating the release of histamine in the brain.

Binding studies indicate that it has no effect on monoamine uptake and no affinity for adrenergic, histaminergic, cholinergic, dopaminergic and benzodiazepine receptors, nor other serotonergic receptors.

Background Clozapine is a widely used atypical neuroleptic with affinity for multiple receptors, including dopamine, serotonin, alpha adrenergic, muscarinic and histaminergic receptors [ 1 2 ] .

The histaminergic neurons of the tuberomammillary nucleus become active during the 'wake' cycle, firing at approximately 2 Hz; during slow wave sleep, this firing rate drops to approximately 0.5 Hz.

Endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors.

However, the synergistic actions of modafinil on both catecholaminergic and histaminergic pathways lower abuse potential as compared to traditional stimulant drugs while maintaining the effectiveness of the drug as a wakefulness promoting agent.

The sleep-promoting neurons are believed to project GABA type A and galanin, two known inhibitory neurotransmitters, to arousal-promoting neurons, such as histaminergic, serotonergic, orexinergic, noradrenergic, and cholinergic neurons (neurons mentioned above).