hereditary non-polyposis colorectal cancer

Recently, a hereditary non-polyposis colorectal cancer gene has been localised to chromosome 2.

Again, molecular biology may be of value in the identification of susceptible members within hereditary non-polyposis colorectal cancer families.

Carlsson C, Nilbert M. "Living with hereditary non-polyposis colorectal cancer; experiences from and impact of genetic testing."

Yang K, Allen B, Conrad P, et al.: Awareness of gynecologic surveillance in women from hereditary non-polyposis colorectal cancer families.

Meiser B, Collins V, Warren R, et al.: Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer.

He is a co-author of the Bethesda Guidelines for the diagnosis of Hereditary non-polyposis colorectal cancer (HNPCC).

Aarnio M, Salovaara R, Aaltonen LA, et al.: Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome.

Reeves SG, Rich D, Meldrum CJ, et al.: IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer.

Aktan-Collan K, Mecklin JP, Järvinen H, et al.: Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.

Kievit W, de Bruin JH, Adang EM, et al.: Current clinical selection strategies for identification of hereditary non-polyposis colorectal cancer families are inadequate: a meta-analysis.

A haematological screening test for FAP is now possible and there is potential to design screening tests for hereditary non-polyposis colorectal cancer and asymptomatic sporadic disease in the future.

Heinimann K, Müller H, Weber W, et al.: Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds.

Mueller-Koch Y, Vogelsang H, Kopp R, et al.: Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer.

Esplen MJ, Madlensky L, Aronson M, et al.: Colorectal cancer survivors undergoing genetic testing for hereditary non-polyposis colorectal cancer: motivational factors and psychosocial functioning.

Mesters I, Ausems M, Eichhorn S, et al.: Informing one's family about genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a retrospective exploratory study.

Soravia C, van der Klift H, Bründler MA, et al.: Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum.

Vasen HF, den Hartog Jager FC, Menko FH, et al.: Screening for hereditary non-polyposis colorectal cancer: a study of 22 kindreds in The Netherlands.

Aktan-Collan K, Haukkala A, Mecklin JP, et al.: Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study.

Beck NE, Tomlinson IP, Homfray T, et al.: Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.

The recent localisation of a hereditary non-polyposis colorectal cancer gene to chromosome 2 provides confirmation of a genetic predisposition to colorectal cancer within certain families and may allow the introduction of effective screening programmes for these people.

Ainsworth PJ, Koscinski D, Fraser BP, et al.: Family cancer histories predictive of a high risk of hereditary non-polyposis colorectal cancer associate significantly with a genomic rearrangement in hMSH2 or hMLH1.

Dunlop MG; British Society for Gastroenterology.Association of Coloproctology for Great Britain and Ireland.: Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome.

Microsatellite instability (MSI) is hallmark of mismatch repair-deficient cancers, which has been observed in all cancers arising from Hereditary Non-polyposis Colorectal Cancer (HNPCC) syndrome, some sporadic colorectal and other cancers [ 38 ] .

MLPA, however, is one of the only accurate, time-efficient techniques to detect genomic deletions and insertions (one or more entire exons), which are frequent causes of cancers such as hereditary non-polyposis colorectal cancer (HNPCC), breast, and ovarian cancer.

The registries provide a service to doctors for identification, surveillance and management of families and individuals with high colorectal cancer risk from Familial Adenomatous Polyposis (FAP) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC).