hepatic stellate cells

The function and role of quiescent hepatic stellate cells is unclear.

In the liver, reelin is localized in hepatic stellate cells.

These hepatic stellate cells, also named lipocytes, have lipid drops in their cytosol.

Hepatic stellate cells are derived from mesenchyme.

It reduces oxidative stress in hepatocytes and hepatic stellate cells (Kitade et al., 2002).

Hepatic stellate cells rest over the Remak trabecules, and they emit extensions to the sinusoids.

Main liver cells are hepatocytes, Kupffer cells, and hepatic stellate cells; each one with a specific function.

Acetaldehyde may be responsible for alcohol-induced fibrosis by stimulating collagen deposition by hepatic stellate cells.

SST inhibits the activation of hepatic stellate cells which produce collagen (Kayano et al., 1998).

Berberine also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury.

The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A).

The senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating the immune system by activating interactions with the NK cells.

Sinusoidal hepatic endothelial cells, Kupffer cells and hepatic stellate cells are some of the non-parenchymal cells that line the liver sinusoid.

Recent evidence suggests a role working together with hepatic stellate cells being a liver-resident antigen-presenting cell that presents lipid antigens to and stimulates proliferation of NKT cells.

SST was found to increase matrix metalloproteinases activity with reduced tissue inhibitors of metalloproteinases activities on hepatic stellate cells possibly via P38 pathway (Sakaida et al., 2004).

Pancreatic stellate cells (PaSCs or PSCs) are myofibroblast-like cells that can switch between the quiescent and activated phenotypes, like hepatic stellate cells.

Hepatocytes constitute about 80% of the cell population of the liver, with the other 20% being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly characteristic of the liver, but are present in the liver samples.

More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence of these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb-hallmarks of cellular senescence.