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Capillary deposition of C4d complement fragment and early renal graft loss.
For de novo diabetic ketoacidosis, gender and graft loss were not significant, and cadaver donor was significant.
Quinolone antibiotics: Ciprofloxacin (Cipro) was shown to significantly lower viral loads but no data on survival and graft loss exist.
In Cox Regression analysis, factors that were positively associated with total rates of hospitalized diabetic ketoacidosis were younger age, graft loss, African American race, more recent year of transplant, lower body mass index, and female gender.
Single center study showed renal allografts were preserved in 8/8 individuals managed with reduction in immunosuppression while graft loss occurred in 8/12 patients treated with an increase in therapy for what was thought to be organ rejection.
In univariate analysis, factors associated with an increased risk of hospitalized poisonings were low body mass index, graft loss, cadaveric donor, rejection within 6 months after transplant, and diabetes, while male gender was associated with reduced risk of poisoning.
Following kidney transplantation, the ongoing, uncontrolled, chronic complement activation associated with aHUS causes graft loss in 66% of children and 55% of adults, as well as continued inflammatory and TMA insult to other organs.
As noted above, kidney transplantation for aHUS patients with ESRD was rarely considered because of a high incidence of graft loss due to TMA recurrence in the transplanted organ in up to 90% of patients.