glycosylated haemoglobin , auch: glycosylated hemoglobin AmE

The other important development has been the glycosylated haemoglobin level.

It should include assessment and provide feedback on progress with glycosylated haemoglobin levels.

The glycosylated haemoglobin result is markedly elevated, revealing the extent of poor control.

The glycosylated haemoglobin has been a very useful advance for the Type 2 patients with latently poor control.

This reduced level of arachidonic acid showed a negative correlation with glycosylated haemoglobin (Jones et al, 1983).

Particularly suitable candidates are those with unstable diabetes and evidence of poor control with elevated glycosylated haemoglobin levels.

Indications for home monitoring of blood glucose in these patients are a raised glycosylated haemoglobin or a low renal threshold.

In addition, a significant inverse correlation between the platelet-aggregate ratio and glycosylated haemoglobin was found for the whole group (Dettori et al, 1983).

This is an area which has been generally illuminated by the glycosylated haemoglobin level which gives a much surer guide of the true state of glycaemic control.

This 1998 prospective study found that the risk increased by 3.1% (over the background risk of about 16%) for each standard deviation in glycosylated haemoglobin above the normal range.

A positive correlation was found between glycosylated haemoglobin concentration and the prostacyclin concentration necessary to inhibit ADP-induced platelet aggregation by 50 per cent.

Successful therapy is measured by a loss of glycosuria, blood glucose levels less than 10.0 mmol/l postprandially and a glycosylated haemoglobin of 10.0 per cent or less.

Two more recent developments have been home blood glucose monitoring and the glycosylated haemoglobin (HbA 1 ) or fructosamine - indicators of the integrated blood glucose level over the preceding few weeks.

In addition, there was a significant inverse correlation between glycosylated haemoglobin levels and the lag phase, suggesting that the platelets were less sensitive to adrenaline when better glycaemic control had been achieved (Peterson et al, 1977).

Glycosylated haemoglobin is also a product of a nonenzymatic post-translational reaction, and its measurement has been of use in patients with diabetes mellitus as an indicator of the degree of hyperglycaemia during the preceding 8 weeks.

For patients on diet alone a check on the blood glucose and glycosylated haemoglobin by the general practitioner or diabetic clinic will suffice, with the patient testing the urine for glucose twice weekly avoiding using early-morning specimens.

Several studies have sought relationships between glycosylated haemoglobin as a measure of overall glycaemic control and platelet-specific protein levels but no correlations were found (Mathews et al, 1979; Betteridge et al, 1981; Davi et al, 1982).

A group of 92 diabetics were divided into 39 with poor control (glycosylated haemoglobin >9 per cent) and 53 with good control (glycosylated haemoglobin <9 per cent ) and the results of the platelet-aggregate ratio analysed.

Taking our cue from the Cardiff group's vision of a system which 'would recall the patients to see their general practitioner at regular intervals, warn.and request.both clinical information and blood for estimation of glycosylated haemoglobin,' we have developed a system for prompting community care of non-insulin dependent (type II) diabetes.