genome instability

Once a cancer is formed, it usually has genome instability.

The sources of genome instability have only recently begun to be elucidated.

In cancer, genome instability can occur prior to or as a consequence of transformation.

Cancers are known to exhibit genome instability or a mutator phenotype.

Genome instability is also referred to as an enabling characteristic for achieving endpoints of cancer evolution.

However, while subtle defects do not affect growth, they do result in future varying forms of genome instabilities.

Eichler is considered one of the experts in genome instability studies, segmental duplication and structural variation.

Loss of function of this gene leads to mitochondrial genome instability and respiratory incompetence.

Crisis is characterized by gross chromosomal rearrangements and genome instability, and almost all cells die.

Another source of genome instability may be epigenetic reductions in expression of DNA repair genes.

Titia de Lange, for research on telomeres, illuminating how they protect chromosome ends and their role in genome instability in cancer.

Telomeres are necessary at chromosome ends to prevent DNA-damage responses as well as genome instability.

In these cases, it is indicated that the affected organism presents genome instability (also genetic instability, or even chromosomic instability).

Situations of genome instability (as well as aneuploidy) are common in cancer cells, and they are considered a "trademark" for these cells.

Defects in cohesion can increase genome instability, a result consistent with the ties between cohesion and DNA damage pathways.

He is known for pioneering studies on homologous recombination, and for defining the links between recombinational repair and genome instability diseases including cancer.

The presence of an inadequate number of centrosomes is very often linked to the apparition of genome instability and the loss of tissular differentiation.

There may be, in addition, other underlying molecular/genetic changes producing DNA mutations and genome instability, which contribute to initiation and progression of this disease.

RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.

The election committee said that it was "particularly impressed by his pioneering role in establishing the nematode worm, C. elegans, as a model system to study genome instability."

For the majority of cancers, genome instability is reflected at the chromosomal level and is referred to as chromosome instability or CIN.

Genome instability (also "genetic instability" or "genomic instability") refers to a high frequency of mutations within the genome of a cellular lineage.

Genome instability is central to carcinogenesis but also is a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy.

Thus, deficiency in DNA repair causes genome instability and this genome instability is likely the main underlying cause of the genetic alterations leading to cancer.

The process of genome instability often leads to a situation of aneuploidy, in which the cells present a chromosomic number that is either higher or lower than the normal complement for the species.