gastric function

Effects of ginger on motion sickness susceptibility and gastric function.

What was it about that mammy-jamming symbol that upset all his gastric functions?

Studies of such patients may be particularly valuable in allowing a clearer insight into the disturbances of gastric function predisposing to DU.

The vagal trunks were preserved, and gastric function was restored by anastomosis between the antrum and the non-oxynit rumen of the proximal stomach.

Detailed studies of gastric function were performed in these six patients and compared with H pylori positive patients with DU and with healthy volunteers.

Each of these abnormalities of gastric function will increase the duodenal acid load, thus supporting a role for duodenal acidity in the pathogenesis of the ulceration.

The effect of ulcer healing with eradication of Helicobacter pylori (H pylori ) on gastric function was investigated in nine patients with duodenal ulcer disease.

To further elucidate the mechanism of the ulceration in these patients with idiopathic DU, studies of gastric function and of claimed genetic markers for DU were performed.

In the rest of the patients with idiopathic DU three disturbances of gastric function are prevalent: hypergastrinaemia, increased basal and peak acid output, and rapid gastric emptying.

The absence of the blood group A 1 antigen gene is consistent with a genetic basis for the disturbed gastric function linked to the ABO blood group antigen genes.

The fact that pentagastrin increased platelet activating factor precursors would suggest that platelet activating factor may have a role in the gastric functions, in particular gastric acid secretion.

These studies preceded the recognition of H pylori and its role in gastroduodenal disorders, and most did not consider the effect of the histological condition of the gastric mucosa on gastric function.

Pavlov investigated the gastric function of dogs, and later children, by externalizing a salivary gland so he could collect, measure, and analyze the saliva and what response it had to food under different conditions.

The ability to visualise the stomach in the fed state may help to increase our knowledge of gastric function, especially in tracing the passage of gastric chyme during the initial stages of digestion.

Detailed studies of gastric function were not performed in the H pylori negative patients with DU in whom an explanation for their ulcer disease was apparent (NSAIDs use, Crohn's disease, or Zollinger-Ellison syndrome).

Our data, therefore, show that subjects with H pylori infection who develop duodenal ulceration have two disturbances of gastric function:(1) increased release of gastrin by the antral mucosa and (2) an exaggerated acid response to stimulation by gastrin.

The difference between the studies may be explained by the fact that we adopted more stringent criteria for assessing H pylori state and also assessed gastric function only in H pylori negative patients with DU who had no other explanation for their ulcer disease.

Recent studies have examined separately the influence of H pylori and age on both gastric function and histology but the complex inter-relationship between H pylori infection, gastric morphology, gastric secretory function, and ageing have not been well defined.

Another problem with the vast number of previous publications on disturbed gastric function patients with DU is that a high proportion of the so called normal controls will have had disturbed gastric function due to unrecognised H pylori infection.

In conclusion, three abnormalities of gastric function are prevalent in patients with H pylori negative idiopathic DU disease - hypergastrinaemia, increased acid secretion, and the one feature distinguishing them from H pylori positive patients with DU - rapid gastric emptying of both liquids and solids.

In the subgroup of these H pylori negative patients with DU in whom no cause for their ulcer disease was identified, detailed studies of gastric function have been performed and compared with those in patients with DU with H pylori infection as well as with healthy volunteers.