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Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.
Ascher and colleagues posit that ganglionic blockade by SGTX results from binding to the closed state of the channel-receptor complex, possibly to the receptor itself.
The ganglionic blockade of nAChRs by SGTX is similar to that of IS-toxin, a structurally similar compound derived from the same mollusk, Babylonia japonica.
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