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Instead, Glu-537 is the actual nucleophile, binding to a galactosyl intermediate.
In work he has not yet published, he found that the mice that lack the galactosyl transferase protein were fertile.
-Increased expression of H-transferase (α 1,2 fucosyltransferase), an enzyme that competes with galactosyl transferase.
A sugar can be attached to ceramide (glycosylation) through the action of the enzymes, glucosyl or galactosyl ceramide synthases.
But ZRK is different from sp56, and both are different from Dr. Shur's galactosyl transferase.
Autosomal recessive disorder; beta-galactosidase deficiency; neuronal storage of GM1 ganglioside and visceral storage of galactosyl oligosaccharides and keratan sulfate.
Most non-primates contain this enzyme thus, this epitope is present on the organ epithelium and is perceived as a foreign antigen by primates, which lack the galactosyl transferase enzyme.
Studies of E. coli lactase have proposed that hydrolysis is initiated when a glutamate nucleophile on the enzyme attacks from the axial side of the galactosyl carbon in the β-glycosidic bond.
Dr. Silver said he doubted the results published by Dr. Burks and Dr. Saling and that he had problems with Dr. Shur's data as well because of the ubiquity of galactosyl transferase.