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The main tool used for the construction of free dimension is free entropy.
The relevant thermodynamic potential is the free energy (or the free entropy).
A free entropy is generated by a Legendre transform of the entropy.
Free entropy - an entropic thermodynamic potential analogous to the free energy.
In mathematics, free entropy means something quite different: it is a generalization of entropy defined in the subject of free probability.
The evidence at present therefore suggests that free enthalpy or free entropy would be better parameters to use than free volume, but that it is not possible to choose between them.
As a result it is often found in "turns" of proteins as its free entropy (ΔS) is not as comparatively large to other amino acids and thus in a folded form vs. unfolded form, the change in entropy is less.