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It contains three components: the macula densa, juxtaglomerular cells, and extraglomerular mesangial cells.
Adenosine may then bind to adenosine A receptors on extraglomerular mesangial cells, triggering a rise in intracellular calcium levels.
Extraglomerular mesangial cells (also known as Lacis cells, Goormaghtigh cells, or Polkissen cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.