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Bisphenol A compounds with lower degrees of bromination seem to exhibit greater estrogenicity.
Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women.
The first evidence of the estrogenicity of bisphenol A came from experiments on rats conducted in the 1930s, but it was not until 1997 that adverse effects of low-dose exposure on laboratory animals were first reported.
More studies of the individual components of the mixture and testing of a standard formulation that is free of contaminants are needed before any conclusions can be reached about the level of cytotoxicity, antineoplasticity, or estrogenicity of PC-SPES.