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Congeners that show estrogenic effects bind to the 17 β estradiol receptor.
Yet, forms of the estradiol receptor of differing stability have been detected in human placental tissue [ 14 ] .
Phytochemicals in black cohosh both decrease LH (thereby shifting the estrogen/progesterone ratio towards estrogens, an effect opposite in some ways to chaste berry) and occupy estradiol receptors.