erythromelalgia

A partial list of diseases known to precipitate erythromelalgia is below.

An effective, though not recommended, treatment for erythromelalgia symptoms is cooling of the affected area.

The first reported case was in 1878 by Mitchell who suggested the term 'erythromelalgia.'

In 1892 he provided an early description of erythromelalgia, which was once referred to as "Gerhardt's disease".

Primary conditions that have been shown to elicit erythromelalgia are listed in diagnosis, below.

Once it has been established that it is not secondary erythromelalgia - see below - then a programme of management can be put in place.

Some diseases present with symptoms similar to erythromelalgia.

The specific underlying cause of erythromelalgia remains unknown.

For primary erythromelalgia, attacks can last from an hour to months at a time and occur infrequently to frequently with multiple times daily.

How this occurs in secondary erythromelalgia is poorly understood and may be specific to the underlying primary condition.

Primary erythromelalgia is a better understood autosomal dominant disorder.

This section pertains solely to primary erythromelalgia as the secondary form is too poorly understood.

Primary erythromelalgia management is symptomatic, i.e. treating painful symptoms only.

Although erythromelalgia typically affects both sides of the body (bilateral), it may sometimes involve only one side (unilateral).

The resulting syndrome of fungus-induced erythromelalgia lasted from 8 days to 5 months, although one person exhibited symptoms for three years.

Research into the genetic mutations continues but there is a paucity of clinical studies focusing on living with erythromelalgia.

There is much urgency within pharmaceutical companies to provide a solution to those who suffer with pain such as that with erythromelalgia.

For secondary erythromelalgia, attacks typically precede and are precipitated by the underlying primary condition.

Mitchell's disease (erythromelalgia) is named after him.

In rural areas of southern China, outbreaks of erythromelalgia have occurred during winter and spring at 3-5 year intervals among secondary school students.

Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene 'Nav1.7'.

High-dose oral magnesium treatment of chronic, intractable erythromelalgia.

The result was in contrast with the genetic basis of primary erythromelalgia in which the disorder results from gain-of-function mutations.

As can be seen from table 1, the primary effect of erythromelalgia mutations is Na1.7 channels that activate at more hyperpolarized potentials.

Mitchell's disease - erythromelalgia.