epidural administration

The evidence is mixed concerning the safety and efficacy of ESI therapy since all steroid injectates, no matter the manufacturer, are not FDA approved for epidural administration.

Epidural administration of HWTX-I in rats with chronic neuropathic pain blocked heat hyperalgesia and mechanical allodynia in the injured hindpaw of rats, indicating that epidurally administered HWTX-I could alleviate neuropathic pain.

The preservatives and suspension agents found in all steroid injectates, which aren't indicated for epidural administration by the U.S. Food & Drug Administration due to reports of severe adverse events including arachnoiditis, paralysis and death, have now been directly linked to the onset of the disease following the initial stage of chemical meningitis.