Evidence has shown that at least two smallpox epidemics had killed the majority of the Kaurna population prior to 1836.
Research on the remains combined with historical records shows that smallpox epidemics hit the tribe in 1778, 1800 and 1836.
It's the law that everybody in the republic has to have been vaccinated inside of the last five years to prevent smallpox epidemics.
Look at the thousands who have lost their eyesight on account of the ravages caused by smallpox epidemics.
At the time the people on Kyushu were experiencing hard times after the smallpox epidemics, years of drought and bad harvest.
Meanwhile the Kaw faced smallpox epidemics in 1827-1828 and 1831-1832, which killed about 500.
In 1738 and 1739 smallpox epidemics broke out among the Cherokee, who had no natural immunity.
New England suffered smallpox epidemics in 1677, 1689-90, and 1702.
Their numbers were greatly reduced by smallpox epidemics in 1865 and 1898.
As noted, smallpox epidemics and social disruption reduced the population.