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Those causing neuroinvasive disease symptoms include the enterovirus infection and bacterial meningitis.
A number of studies have investigated enterovirus infections in CFS patients, but the results are contradictory and no causal relationship has been demonstrated.
Enterovirus infection is diagnosed mainly via serological tests such as ELISA and from cell culture.
Acute enterovirus infections such as Coxsackievirus B3 have been identifies as the cause of virally induced acute myocarditis, resulting in dilated cardiomyopathy.
In addition to the genetic defects in dystrophin or other cytoskeletal proteins, a subset of dilated cardiomyopathy is linked to enteroviral infection in the heart, especially coxsackievirus B. Enterovirus infections are responsible for about 30% of the cases of acquired dilated cardiomyopathy in humans.