endometrial stromal sarcoma

Hormonal therapy with progestins and antiestrogens has been used for the treatment of endometrial stromal sarcomas.

Subtypes include leiomyosarcomas, endometrial stromal sarcomas, carcinosarcomas and "other" sarcomas.

If the lesion originates from the stroma of the uterine lining it is an endometrial stromal sarcoma.

Endometrial stromal sarcomas and uterine adenosarcomas are classified as above, with the exception of different classifications for Stage I tumors.

Endometrial stromal sarcomas originate from the connective tissues of the endometrium, and are far less common than endometrial carcinomas.

Low-grade endometrial stromal sarcoma consists of cells resembling normal proliferative phase endometrium, but with infiltration or vascular invasion.

Endometrial stromal sarcoma is a rare endometrial tumor arising from the stroma (connective tissue) of the endometrium rather than the glands.

In contrast to endometrial carcinomas, the uncommon endometrial stromal sarcomas are cancers that originate in the non-glandular connective tissue of the endometrium.

Undifferentiated uterine sarcoma, or undifferentiated (high-grade) endometrial stromal sarcoma, does not resemble normal endometrial stroma and behaves much more aggressively, frequently metastasizing.

Katz L, Merino MJ, Sakamoto H, et al.: Endometrial stromal sarcoma: a clinicopathologic study of 11 cases with determination of estrogen and progestin receptor levels in three tumors.

Sutton G, Blessing JA, Park R, et al.: Ifosfamide treatment of recurrent or metastatic endometrial stromal sarcomas previously unexposed to chemotherapy: a study of the Gynecologic Oncology Group.