emetogenic

Two clinical studies evaluated Emend™ in 1103 patients with highly emetogenic chemotherapy.

Similar results were reported for the study that evaluated 866 breast cancer patients receiving moderately emetogenic chemotherapy.

Effective anti-emetic therapy improves quality of life after moderately emetogenic chemotherapy.

Exposure to stimuli associated with the emetogenic agent is then sufficient to trigger nausea and vomiting.

"These results are of special interest in light of ensuring an even more effective supportive care to patients undergoing high emetogenic chemotherapy.

Some highly emetogenic agents and chemotherapy regimens include:

Up to 20% of patients receiving highly emetogenic agents in this era postponed, or even refused, potentially curative treatments.

The intravenous anaesthetic propofol is currently the least emetogenic general anaesthetic.

Pemetrexed's emetogenic effects are managed with prophylactic antiemetics.

Emetogenic drugs commonly used in anaesthesia include nitrous oxide, physostigmine and opioids.

An additional study, P071, was conducted in patients receiving moderately emetogenic chemotherapy including cyclophosphamide and possibly doxorubicin or epirubicin.

Doxorubicin and cyclophosphamide are as emetogenic as cisplatin, and preventive drugs should always be considered.

The emetogenic potential of radiotherapy is classified into high, moderate, low and minimal risk depending on the site of irradiation:

Randomized, double blind controlled trial testing the dose response and overall efficacy of batanopride in patients receiving moderately emetogenic chemotherapy.

Chemotherapy-induced nausea and vomiting resulting from treatment with highly emetogenic cytotoxic drugs can be prevented or effectively treated in 70 to 80% of affected people.

The refiled submission included a new clinical study on moderately emetogenic chemotherapy-associated nausea and vomiting, and further safety data.

Dacarbazine is considered to be highly emetogenic, and most patients will be pre-medicated with antiemetic drugs like palonosetron or aprepitant.

Overall, for the prevention of CINV due to highly emetogenic chemotherapy, the benefit/risk assessment is considered to be acceptable.

By far the most important factor which determines the degree of CINV is the emetogenic potential of the chemotherapeutic agents used.

Is progressive muscle relaxation (PMR) an effective anti emetic therapy for patients receiving highly emetogenic cancer chemotherapy?

A randomized, double-blinded study comparing six doses of batanopride (BMY-25801) with methylprednisolone in patients receiving moderately emetogenic chemotherapy.

Dolasetron vs ondansetron with and without dexamethasone in the prevention of nausea and vomiting in patients receiving moderately emetogenic chemotherapy.

The product has shown to be effective in preventing both acute and delayed CINV in patients receiving moderately emetogenic chemotherapies.

For Level III single agents and moderately emetogenic combination chemotherapy regimens, the use of 5-HT3 antagonists may be required.

Metoclopramide treats nausea and vomiting associated with conditions such as uremia, radiation sickness, malignancy, labor, infection, migraine headaches, and emetogenic drugs.