effector molecule

A number of potential downstream Rho effector molecules have been identified recently.

Background Ribozymes whose activities are modulated by effector molecules have previously been engineered.

Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules.

Binding of effector molecules either increases or decreases RNR activity.

However, models that suggest molecular rearrangement, reorganization, and pre-complexing of effector molecules are beginning to be accepted.

A "killer effector molecule" has been identified that may play a role in the activation of cytotoxic lymphocytes.

In some cases, proteins can be considered to function as effector molecules, especially in cellular signal transduction cascades.

Does it activate the target, or in some way change the target (or effector molecule's) conformation?

Binding of effector molecules may be affected in a similar manner if the phosphorylated residue makes part of the allosteric site.

Uncoupling of receptor effector molecules.

This could occur by the release of limited effector molecules shared between the two GTPases, possibilities that are currently under investigation.

An allosteric site is a site on an enzyme, unrelated to its active site, which can bind an effector molecule.

In this manner, effector molecules act as ligands that can increase or decrease enzyme activity, gene expression, or cell signalling.

HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.

Applications The ability to engineer Group I introns to be responsive to effector molecules has numerous potential applications.

These genes are activated by the presence of lactose in the cell which acts as an effector molecule that binds to LacI.

NF-κB is a key transcription factor and effector molecule involved in responses to cell stress, consisting of a p50/p65 heterodimer.

Effector molecules can also directly regulate the activity of some mRNA molecules (riboswitches).

In biochemistry, an effector molecule is usually a small molecule that selectively binds to a protein and regulates its biological activity.

The role of specific chemokines in arthritis is still controversial, and further investigation is necessary to delineate to specific roles of these effector molecules.

However, it is also warned that the design and delivery of small RNA effector molecules should be carefully considered in order to ensure safety and efficacy.

One mechanism for steepening the response of an effector molecule is to require that more than one molecule bind to the target to induce a response.

Thus, an mRNA that contains a riboswitch is directly involved in regulating its own activity, in response to the concentrations of its effector molecule.

HDIs can alter the degree of acetylation nonhistone effector molecules and, therefore, increase or repress the transcription of genes by this mechanism.

Molecules spotted on a pMHC cellular microarray can be classified as capture molecules, detector molecules and effector molecules.