diphtheria toxin

It is the target of diphtheria toxin and exotoxin A.

In Constantinople he also worked on improving methods for preparation of diphtheria toxin.

The crystal structure of the diphtheria toxin homodimer has been determined to 2.5 A resolution.

The drug denileukin diftitox uses diphtheria toxin as an antineoplastic agent.

The dtxR protein regulates the expression of diphtheria toxin in response to environmental iron concentrations.

Toxins such as diphtheria toxin interfere with cellular processes and eventually induce apoptosis.

For example, diphtheria toxin molecules do not bind with mouse cells, thus mice are unaffected by this poison.

Diphtheria toxin is extraordinarily potent.

Elek's test for toxogenecity is used to determine whether the organism is able to produce the diphtheria toxin or not.

Perhaps the most notable one is C. diphtheriae, which acquires the capacity to produce diphtheria toxin only after interacting with a bacteriophage.

(The mechanism of the toxin is similar to that of Diphtheria toxin.)

Diphtheria toxin was discovered in 1890 by Emil Adolf von Behring.

The horses and cows were needed to produce the smallpox and diphtheria toxins and serums.

The diphtheria toxin gene is encoded by a bacteriophage found in toxigenic strains, integrated into the bacterial chromosome.

He became a research fellow at Leeds School of Medicine after the war, working with tubercle bacillus and diphtheria toxins.

Denileukin diftitox: A biologic therapy that combines diphtheria toxin and interleukin-2 protein to target and kill cancer cells.

Diphtheria toxin is produced by C. diphtheriae only when infected with a bacteriophage that integrates the toxin-encoding genetic elements into the bacteria.

This can bind to Interleukin-2 receptors and introduce the diphtheria toxin into cells that express those receptors, killing the cells.

It is ADP-ribosylated by diphtheria toxin, hence the name, which renders the elongation factor inactive.

In order to determine the effectiveness of diphtheria antiserum, an invariable concentration of diphtheria toxin was required.

In the 1880s and 1890s, Emil von Behring isolated the diphtheria toxin and demonstrated its effects in guinea pigs.

Certain toxins, such as alcohols, carbon tetrachloride, aspirin, and diphtheria toxin, interfere with cellular machinery involved in lipid metabolism.

"Jim" was the name to which a former milk wagon horse, who was used to produce serum containing antibodies against diphtheria toxin, was trained to respond.

An example of a neutralizing antibody is diphtheria antitoxin, which can neutralize the biological effects of diphtheria toxin.

The structures of other multimeric membrane proteins (such as diphtheria toxin) provide the answer to how PA manages to span the membrane.