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Distinctive clinical features of Graves' disease include the presence of ophthalmopathy, diffuse goitre and pretibial myxoedema.
Diffuse goitre may be seen with other causes of hyperthyroidism, although Graves' disease is the most common cause of diffuse goitre.
A "diffuse goitre" is a goitre that has spread through all of the thyroid (and can be a "simple goitre", or a "multinodular goitre").