dicentric chromosome

Dicentric chromosome is an aberrant chromosome having two centromeres.

After mitotic arrest at 48h with colchicine, the percentage of cells with dicentric chromosomes was determined (Fig. 1).

As telomeres shorten with continued cell divisions, the chromosome-ends fuse forming dicentric chromosomes.

The plates also reduce the risk of lethality caused by the formation of dicentric chromosomes, acentric fragments, and other unstable aberrations.

From each venous sample, 100 sets of chromosomes were examined, and counts made of the frequency of cells containing dicentric chromosomes with dissimilar chromosome fragments.

Breakage-fusion-bridge creates several identifiable cytogenetic abnormalities, such as anaphase bridges and dicentric chromosomes, which can be seen in progress using methods that have been available for decades.

Loss of capping proteins causes telomere shortening and inappropriate joining by NHEJ, producing dicentric chromosomes which are then pulled apart during mitosis.

We studied persistence of dicentric chromosomes in the CD45RA and CD45R0 subsets after therapeutic X-ray irradiation in a group of 19 cancer patients.

During early prophase the broken chromosome undergoes normal replication, but during metaphase the broken ends can fuse leading to the formation of a dicentric chromosome and an acentric fragment.

We suggest therefore that the rates of loss of dicentric chromosomes from the two subsets support the idea that reversion from the CD45R0 to CD45RA phenotype occurs in vivo.

Dicentric chromosomes form when two chromosome segments (from different chromosomes or from the two chromatids of a single one), each with a centromere, fuse end to end, with loss of their acentric fragments.

For example Telomeric double stranded breaks/ telomeric dysfunctions can cause sister chromatid/ end to end fusion and the formation of anaphase bridges resulting in dicentric chromosomes that can result in further rearrangements .

The formation of a neocentromere must be coupled with or followed or proceeded by the inactivation of the centromere since chromosomes with two functional centromeres (Dicentric chromosome) will result in chromosome breakage during mitosis.