depolarization wave

Physiologically, the normal electrical depolarization wave is delayed at the atrioventricular node to allow the atria to contract before the ventricles.

Normally impulses pass through both ventricles almost simultaneously and the depolarization waves of the two ventricles partially cancel each other out in the ECG.

Recall that excitatory postsynaptic potentials caused by glutamatergic inputs at the dendrites of the spiny neurons only cause an action potential when the depolarization wave is strong enough upon entering the cell soma.

From previous evidences we speculate that carbenoxolone, by closing GJ channels, possibly directly or via the GABAergic system, inhibits the spread of depolarization waves in the CNS and peripheral organs.