deoxycytidine kinase

Because of its similar structure acyclovir can also receive a phosphate group from the thymidine/ deoxycytidine kinase enzyme.

Deoxycytidine can be phosphorylated by deoxycytidine kinase (DCK).

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.

Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.

Deoxycytidine kinase, also known as DCK, is an enzyme which in humans is encoded by the DCK gene.

Before these precursors can be incorporated into viral DNA, they must be phosphorylated Certain viruses (the herpes group for example) produce an enzyme called thymidine/ deoxycytidine kinase, which is responsible for adding a phosphate group to these two precursors.