deoxycorticosterone
deoxycortone

Deoxycorticosterone is another important member of this class.

It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase.

However, it fully restored erectile function in rats developing hypertension due to injection of deoxycorticosterone acetate.

Other 5a-reductase substrates include progesterone, androstenedione, epi-testosterone, cortisol, aldosterone, and deoxycorticosterone.

The primary endogenous mineralocorticoid is aldosterone, although a number of other endogenous hormones (including progesterone and deoxycorticosterone) have mineralocorticoid function.

ACTH, a pituitary peptide, also has some stimulating effect on aldosterone probably by stimulating deoxycorticosterone formation which is a precursor of aldosterone.

This should make pH regulation much easier (unlike the normal potassium-deficiency situation, in which two sodium ions move in for each three potassium ions that move out-closer to the deoxycorticosterone effect).

Correspondingly, repeated administration of the mineralocorticosteroid hormone deoxycorticosterone acetate (DOCA) produces a moderate increase in HSD2 neuron activity (c-Fos) without any sodium or volume deficit.