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It has been suggested that the disease is primarily auto-immune in nature, being a delayed hypersensitivity reaction to any of the above agents.
It can trigger allergic reactions and delayed hypersensitivity reactions in people sensitive to horse proteins.
An idiosyncratic, delayed hypersensitivity reaction has been implicated in the pathophysiology of Stevens-Johnson syndrome.
Gluten, the protein found in wheat, can lead to a damaged intestinal lining owing to a delayed hypersensitivity reaction, otherwise known as coeliac disease.
As such, ACD is termed a Type IV delayed hypersensitivity reaction involving a cell-mediated allergic response.
A MELISA test measures a so-called Type-IV delayed hypersensitivity reaction.
There are both immediate hypersensitivity reactions (types I and III) and delayed hypersensitivity reactions (type IV) to mosquito bites.