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There are also effects associated with deformability of red blood cells that might increase this force.
Some deformability tests may be more physiologically-relevant than others for given applications.
Deformability is reduced by a factor of 3-4 between 37 and 41 degrees Celsius.
Relative membrane deformability is less than 10% of uninfected erythrocytes.
The deformability of the membrane is also dependent on the temperature and decreases with increased temperature.
Moreover, some tests may track how deformability itself changes as conditions change and/or as deformation is repeated.
These proteins appear to affect membrane deformability.
Epinephrine-induced reversal of aspirin effects on platelet deformability.
Thus for meaningful "apples-to-apples" comparisons involving cell deformability, it is important to utilize the same qualitative approach.
Erythrocyte deformability is altered under various pathophysiological conditions.
The viscoelasticity of the blood is dominated by the deformability of the red blood cells.
Sickle-cell disease is characterized by extensive impairment in erythrocyte deformability, being dependent on the oxygen partial pressure.
The double-bond index of the red cells increased, indicating an increase in red cell membrane fluidity and deformability.
Both pathways result in membrane loss, decreased surface area, and formation of spherocytes with decreased deformability.
Erythrocyte deformability is an important determinant of blood viscosity, hence blood flow resistance in the vascular system.
Another beneficial consequence of strong bilayer deformability is the increased Transfersome affinity to bind and retain water.
It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction.
Ektacytometry based on laser diffraction analysis is a commonly preferred (and a fairly direct) method for measuring deformability.
The membrane of the red blood cell plays many roles that aid in regulating their surface deformability, flexibility, adhesion to other cells and immune recognition.
Red blood cells have unique mechanical behavior, which can be discussed under the terms "erythrocyte deformability" and "erythrocyte aggregation".
Erythrocyte deformability has also been demonstrated to be impaired in diabetes, peripheral vascular diseases, sepsis and a variety of other diseases.
With very low shear rates, the viscoelastic property of blood is dominated by the aggregation and cell deformability is relatively insignificant.
The influence of aggregation properties on the viscoelasticity diminish and the influence of red cell deformability begins to increase.
A polymer can possess a wide range of material properties and of these the hardness, deformability, toughness, and ultimate strength, are amongst the most significant.
Pentoxifylline and isoxsuprine both have anti-inflammatory effects, and may help improve circulation by improving deformability of red blood cells.