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Methotrexate has, like all cytotoxic substances, a broad array of possible adverse effects.
The modified suicide gene converts the non-toxic prodrug into a cytotoxic substance.
Azathioprine is the main immunosuppressive cytotoxic substance.
In addition to being able to destroy infectious organisms through cell to cell contact via phagocytosis, microglia can also release a variety of cytotoxic substances.
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