cryoprecipitate

Factor concentrates are expensive compared to fresh frozen plasma and cryoprecipitate.

Cryoprecipitate contains all clotting factors, so it can be used to treat many varieties of blood disorders.

And sure enough, about a year later Judith Graham Pool discovered cryoprecipitate.

But compared to factor concentrates and recombinant products, a relatively large amount of cryoprecipitate is still required to increase clotting factors to a safe level.

Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly used coagulation factor products.

Indications for giving cryoprecipitate include:

A bleeding episode requires less cryoprecipitate than fresh frozen plasma because cryoprecipitate has been concentrated.

Early blood transfusions consisted of whole blood, but modern medical practice commonly uses only components of the blood, such as fresh frozen plasma or cryoprecipitate.

Died: Judith Graham Pool, 56, American physician who developed the cryoprecipitate, a blood clotting agent for treatment of hemophilia.

For treatment of hemophilia A, cryoprecipitate or factor VIII concentrates, heated or unheated, are available.

To seal the membranes, they use the woman's own blood platelets, the cell-like particles that help form clots, and a substance called cryoprecipitate, also made from her blood.

Instead of using cryoprecipitate, he uses two other commercially prepared substances: collagen, a protein found in connective tissue, and fibrin, a blood protein that aids clotting.

Judith Graham Pool publishes her discovery of cryoprecipitate, a frozen blood clotting product made from plasma primarily to treat Hemophilia hemophiliacs around the world.

Fresh frozen plasma and cryoprecipitate are the mainstay of therapy for Factor XIII deficiency, but carries risk related to transfusion.

The term cryosupernatant (also called cryo-poor plasma, cryoprecipitate depleted) refers to plasma from which the cryoprecipitate has been removed.

In patients with fibrinogen deficiency, the correction of bleeding is possible by infusion of fresh frozen plasma (FFP), cryoprecipitate (a fibrinogen-rich plasma fraction) or by fibrinogen concentrates.

Thus, removing these women from the donor pool for frozen plasma was proposed as a solution to the TRALI problem (the women's plasma could still be used for production of other components, including cryoprecipitate).

People with haemophilia were at risk of HIV infection before October 1985, because they regularly received injections of contaminated blood products which help their blood to clot (Factor VIII and cryoprecipitate).

The Atlanta center collects blood from donors in Georgia and northern Florida, and processes 1,200 500-milliliter units of it a day, separating it into its components and repackaging it into packed red blood cells, platelets, fresh-frozen plasma and cryoprecipitate, or clotting proteins.