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It uses the energy that is stored in the electrochemical gradient of sodium (Na) by allowing Na to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca).
We therefore propose the stoichiometry shown in Fig. 4 g, in which uptake of one glutamate is accompanied by two Na + and by the countertransport of a K + and an OH -(or occasionally an HCO in vivo).
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