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In borderline cases concerning for CAH, a corticotrophin stimulation test may be performed.
Psoralidin inhibits forskolin-induced corticotrophin releasing factor gene transcription.
A clearer rationale underlies the development of antidepressants that block corticotrophin releasing factor, a hormone released in the brain during stress.
Dr. Vale's first target was the master hormone known as CRF, or corticotrophin releasing factor, which integrates and controls the body's response to stress.
CRHBP is a corticotrophin releasing hormone binding protein which could possibly play a role in a signal cascade that involves or activates C11orf73.
An overproduction of corticotrophin, the hormone that controls the adrenal gland by the pituitary gland, which stimulates the adrenal glands to produce the corticosteroids, could be of one cause.
In 1988, early stress researchers at Duke University attempted to trace the connection by injecting rats with corticotrophin releasing factor (CRF), a chemical that triggers the release of adrenaline and other brain chemicals in times of stress.
Alternatively, in addition to stimulating the HPG axis, male pheromones could act centrally to alter neuroendocrine control of growth and metabolism (e.g. via growth hormone releasing hormone, thyroid hormone releasing hormone, or corticotrophin releasing hormone).
Additional genes that have been shown, either by in vitro or in vivo studies, to be regulated by epigenetic mechanisms include leptin, SOCS3, glucose transporter (GLUT)-4, POMC, 11-β-hydroxysteroid dehydrogenase type 2 and corticotrophin releasing hormone.