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Therefore, the cortical reaction prevents polyspermic fertilisation, a lethal event.
The cortical reaction is exocytosis of the egg's cortical granules.
In mice, the zona reaction is the equivalent to the cortical reaction in sea urchins.
Two highly productive lines of research demonstrate that ginseng increases the efficiency both of adrenal cortical reactions to stress, and of the production of energy during exhaustive physical work.
In the cortical reaction, cortical granules directly beneath the plasma membrane are released into the space between the plasma membrane and the vitelline membrane (the perivitelline space).
Nevertheless, polyspermy preventing mechanisms are essential in mammals; a secretion reaction, the "cortical reaction" modifies the extracellular coat of the egg (the zona pellucida), and additional mechanisms that are not well understood modify the egg's plasma membrane.
This itself triggers the cortical reaction, which results in depositing several substances onto the vitelline membrane through exocytosis of the cortical granules, transforming it into a hard layer called the "fertilization membrane", which serves as a barrier inaccessible to other spermatozoa.