coronary perfusion

We need a minimum amount of coronary perfusion pressure to achieve ROSC.

Coronary perfusion pressures are decreased by these factors, which also increase myocardial oxygen consumption, possibly leading to left ventricular hypertrophy.

Retrograde coronary perfusion at a constant perfusion pressure of 55 mmHg with oxygenated modified Krebs solution was started.

SAI and DAI are in a close relation to the coronary perfusion, because it is mainly maintained in diastole.

Coronary Perfusion Pressure (CPP) is a part of normal blood pressure, that is specifically responsible for coronary blood flow.

Applying permissive hypotension to the latter patient category may result in decreased coronary perfusion and result in ischemic damage to the heart and potentially myocardial infarction (heart attack).

Coronary perfusion pressure (CPP) refers to the pressure gradient that drives coronary blood pressure, meaning the difference between the aortic diastolic pressure and the right atrial pressure.

Initially, this helps compensate for heart failure by maintaining blood pressure and perfusion, but places further strain on the myocardium, increasing coronary perfusion requirements, which can lead to worsening of ischemic heart disease.

If a sufficient flow of oxygen is met and the resistance in the coronary circulation rises (perhaps due to vasoconstriction), then the coronary perfusion pressure (CPP) increases proportionally, to maintain the same flow.

Results of animal models have supported the use of either vasopressin or epinephrine in cardiac arrest resuscitation attempts, showing improved coronary perfusion pressure and overall improvement in short-term survival as well as neurological outcomes.

The significant increase in the pressure gradient between radial artery pressures (generally equal to aortic pressures) and the right intraventricular pressures, whose gradient is considered a good index of coronary perfusion pressure [ 6], may have improved the right coronary driving pressure.

Systemic hypotension may reduce coronary perfusion; in the CONSENSUS II trial there was an increased incidence of first dose hypotension in the enalapril group (10.5% v 2.5% in placebo group) and mortality was increased in patients who showed this effect.

One such device, known as the LUCAS, was developed at the University Hospital of Lund, is powered by the compressed oxygen supplies already standard in ambulances and hospitals, and has undergone numerous clinical trials, showing a marked improvement in coronary perfusion pressure and return of spontaneous circulation.