convulsant

It might be a more powerful convulsant than strychnine.

Its effect is similar to picrotoxin, another cage convulsant.

The convulsant scorched him like acid.

It is a potent convulsant and excitotoxin and is used in scientific research.

Just a recording of me playing guitar along with Trevor Dunn s Trio Convulsant.

A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant.

In animals it is a powerful convulsant, robustly enhancing epileptiform activity and inducing seizures, but without producing any apparent neuronal death.

Tonight at 7, with Trevor Dunn's Trio Convulsant and Vaz opening; tickets are $20 (Pareles).

The bassist Trevor Dunn divides much of his time between the experimental jazz of his Trio Convulsant and the surrealist metal of the band Fantômas.

ATP Nightmare Before Christmas - 12-05-08: Madlove, Trevor Dunn s (Trio Convulsant, Mr. Bungle)new group as of...

Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.

It acts as a partial inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant.

This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.

Fariello RG, Golden GT, Pisa M. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.

Trevor Dunn joined Patton in Fantômas and recently in Tomahawk as well as forming his own jazz band, Trevor Dunn's Trio Convulsant; he also occasionally played bass with Secret Chiefs 3.

It is not active as an opioid agonist, but does have some action as a convulsant, which does not appear to be mediated through opioid receptors; it is mediated by GABA/glycinergic system.

At very high doses (360 mg/kg of body weight), 4-methylimidazole is a convulsant for rabbits, mice and chicks, and was the likely cause of acute intoxication observed in cattle fed with ammoniated, sugar-containing cattle feed supplements in the 1960s.

It has convulsant effects with a similar mechanism of action to strychnine.

At high dosages, it can act as a convulsant agent in mice and rats.

However it may also have convulsant effects.

These neurons become highly sensitized to convulsant agents.

Phenylsilatrane is a convulsant chemical which has been used as a rodenticide.

It acts as a potent antagonist of the glycine receptor, and has powerful convulsant effects.

Sedative yet also convulsant and anxiogenic in mice.

Crimidine is a convulsant poison used as a rodenticide.

Another example is strychnine, a convulsant poison, which acts as an allosteric inhibitor of the glycine receptor.

In general these drugs produce stimulant and convulsant effects, and are mainly used for counteracting overdoses of sedative drugs.

Some sigma receptor agonists-such as cocaine, a weak sigma agonist-exert convulsant effects in animals.

Leaves and fruits contain coriamyrtin a typical convulsant substance one member of picrotoxane sesquiterpenes, was first isolated in 1864.

As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has stimulant and convulsant effects.

However, not all halogenated ethers have anesthetic effects, and some compounds such as flurothyl do the opposite and have stimulant and convulsant effects.

Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.

Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.

For example Sterman has shown that both monkeys and cats who had undergone SMR training had elevated thresholds for the convulsant chemical monomethylhydrazine.

They found that in vivo convulsant potency was strongly correlated to in vitro affinity to the picrotoxin binding site on the GABA-A receptor complex.

Bevan CW, Broadbent JL, Hirst J. A convulsant alkaloid of Dioscorea dumetorum.

However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects.

As such, DMCM has anxiogenic and convulsant properties, and is used in scientific research to induce anxiety so that new anxiolytic medications can be tested, and to produce convulsions so that anticonvulsant medications can be tested.

It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABA ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM.

Interestingly despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity, as well as having analgesic and possible antidepressant, cardioprotective and anti-cancer effects.

EIDA was found to produce similar effects to MDA in animals but with less than half the potency, while the isopropylidinedioxy derivative (IPIDA, IDA) did not substitute for MDA and instead had sedative and convulsant effects.